3,5-二甲基-4-叔丁基-2,6,7-双环硫化磷酸酯的合成

Synthesis of 3,5-dimethyl-4-t-butyl-bicyclophosphorothionate

以乙酰丙酮为起始原料,经烷基化,羟甲基化,还原,最后与PSCl3环合,成功合成了1-硫代-1-磷杂-3,5-二甲基-4-叔丁基-2,6,7-三氧杂双环[2,2,2]辛烷.目标化合物及部分中间体的结构均通过1H NMR、MS进行了结构确证.

Bicyclophosphorothionates are GABA receptor antagonists which show the selectivity between insects and mammals.1-sulfo-1-phosphor-3,5-dimethyl-4-t-butyl-2,6,7-trioxabicyclo octane was synthesized from acetylacetone via alkylation,hydroxymethylation,reduction and cyclization with PSCl3.The target compound is confirmed by 1H NMR,MS spectra.