心血管疾病的血浆内皮素变化及其临床意义

Cardiovascular Changes of Plasma Endothelin and Its Clinical Significance

目的探讨心血管疾病患者血浆内皮素(ET)的变化及其临床意义。方法回顾性分析2008年1月至2009年12月我院收治的179例心血管疾病患者的临床资料,其中急性心肌梗死30例,收缩性心力衰竭21例,高血压病34例,稳定型心绞痛46例及不稳定性心绞痛48例,分别对179例心血管疾病患者和34例正常人进行外周血浆和ET水平的测定。结果稳定型心绞痛,不稳定性心绞痛患者血浆ET水平与正常人比较,差异无统计学意义(P>0.05)急性心肌梗死,高血压病及收缩性心力衰竭患者血浆ET水平明显高于正常人(P<0.01),并且急性心肌梗死。收缩性心力衰竭不同心功能分级及高血压病不同分期之间,随着病情加重,血浆ET水平有升高的趋势。结论血浆ET浓度与心血管疾病患者的病理生理过程存在较为密切的关系。

Objective To evaluate the cardiovascular disease in patients with plasma endothelin（ET）of the change and its clinical significance.Methods A retrospective study from January 2008 to December 2009 in our hospital admitted 179 cases of cardiovascular disease in patients with clinical data,which 30 cases of acute myocardial infarction,21 patients with systolic heart failure,hypertension in 34 cases,46 cases of stable angina and unstable angina in 48 cases,respectively,179 cases of cardiovascular disease and 34 cases of normal peripheral blood plasma and ET levels measured.Results stable angina,unstable angina pectoris plasma ET levels and normal comparison,the difference was not statistically significant （P〉0.05）.acute myocardial infarction,hypertension and plasma ET in patients with systolic heart failure was significantly higher than normal （P〈0.01）,and acute myocardial infarction,cardiac function in different systolic heart failure and high blood pressure in different sub-classification the period between,with the sicker,plasma ET levels are on.Conclusion The concentration of plasma ET in patients with cardiovascular disease,there is the pathophysiological process of closer relations.