清解方用于胰岛素抵抗及早期糖尿病肾病的临床观察

Clinical observation on effects of Qingjiefang on early diabetic nephropathy and insulin resistance

目的 以自拟清热解毒为主的清解方,观察治疗糖尿病肾病及改善胰岛素抵抗的临床疗效.方法 选取64例临床早期糖尿病肾病的患者,随机分为对照组（32例）与治疗组（32例）,对照组子西医基础治疗,治疗组在此基础上加用中药清解方,观察加用中药对前后空腹血糖（FPG）、餐后2 h血糖、糖化血红蛋白（HbAlc）、空腹胰岛素（FINS）、24 h尿微量白蛋白排泄率（UAER）、体重指数（BMI）及胰岛素抵抗指数（IR）的影响.结果 治疗组FINS、IR、UAER下降,与对照组比较差异有统计学意义（P〈0.05）.结论 清解方可改善胰岛素抵抗,治疗早期糖尿病肾病.

Objective To observe the effects of Qingjiefang on insulin resistance and reduction of microalbuminuria in early diabetic nephropathy. Methods A total of 64 patients with early diabetic nephropathy were randomly recruited into a control group and a treatment group. The control group （32 cases） was treated with conventional western medicine, while the treatment group （32 cases） was treated with Qingjiefang based on the control group. The changes of the fasting plasma glucose （FPG）, 2hBG, glycosylated hemoglobin （HbA1C）, fasting Insulin （FINS）, 24 hours urinary albumin excretion rate （UAER）, body mass index （BMI） and insulin resistance （IR） were observed before and after the treatment. Results After the treatment, FINS, IR and UAER were decreased in the treatment group, the comparison with the control group showed significant difference （P〈0.05） . Conclusion Qingjiefang can effectively improve insulin resistance and prevent early diabetic nephropathy.