低分子肝素钙联合降纤酶治疗短暂性脑缺血发作的疗效观察

Efficacy of low molecular calcium combined with defibrase for transient ischemic attack

目的 探讨低分子肝素钙联合降纤酶治疗短暂性脑缺血发作（TIA）的临床效果.方法 将2008年1月-2009年6月间在我院住院治疗的TIA患者70例随机分为观察组和对照组,对照组给予双嘧达莫联合阿司匹林治疗,观察组给予低分子肝素钙联合降纤酶治疗,观察两组疗效.结果 TIA终止小于1 d者观察组26例,对照组16例,两组比较差异有显著性（P〈0.05）.脑梗塞患者观察组1例.对照组8例,两组比较差异有显著性（P〈0.05）.观察组总有效率为97.14%,对照组为77.14%,两组比较差异有显著性（P〈0.05）.两组患者均未见明显的药物不良反应.结论 低分子肝素钙联合降纤酶治疗TIA效果更好,值得应用.

Objective To investigate the efficacy of low molecular calcium combined with defibrase for transient ischemic attack （TIA）. Method 70 patients who were hospitalized from January 2008 to June 2009 were randomly assigned to receive low molecular calcium combined with defibrase （study group）, or dipyridamole plus acenterine （control group）. The efficacy of the two therapies was compared. Results There was a significant difference between the study group and the control group in the number of patients who had TIA cessation within one day or who developed cerebral infarction （26 vs. 16 and 1 vs. 8, P〈0.05 for both comparisons）. The total effective rate differed significantly between the two groups （97. 14% in the study group vs. 76.14% in the control group, P〈0.05）. No marked adverse reactions were found in all the patients. Conclusions Low molecular calcium combined with defibrase for transient ischemic attack has a better efficacy and is worth popularizing.