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类风湿性关节炎治疗药物发展现况及市场趋势 被引量:2

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摘要 1发展概况 类风湿性关节炎是一种慢性、全身性炎症疾病,在全球影响到约0.8%的成人人口,典型发病年龄段在30~50岁。近年来,临床已经认识到,及早进行并采用更具侵袭性的药物治疗是一种成功的类风湿性关节炎治疗策略。
作者 马培奇
出处 《上海医药》 CAS 2010年第6期278-280,共3页 Shanghai Medical & Pharmaceutical Journal
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  • 1陈桂敏,代林刚,贺金.类风湿性关节炎相关机制研究进展[J].海南医学院学报,2007,13(3):292-294. 被引量:10
  • 2TANIGUCHI T,KOBAYASHI T,KONDO J,et aI. Molecular cloning of a porcine gene Syk that encodes a 72-kDa protein-tyrosine kinase showing high susceptibility to proteolysis [J]. J Biol Chern, 1991 , 266 (24) : 15790 - 15796.
  • 3RICCABONI M, BIANCHI I, PETRILLO P. Spleen tyrosine kinases , biology, therapeutic targets and drugs [J]. Drug Discov Today, 2010, 15 ( 13/14) : 517-530.
  • 4KELLY V, GENOVESE M. Novel small molecule therapeutics in rheumatoid arthritis [J]. Rheumatology,2013,52(7) :1155 -1162.
  • 5ARIAS-PALOMO E, RECUERO-CHECA M A, BUSTELO X R, et aI. Conformational rearrangements upon Syk auto-phosphorylation [J]. BBA-Proteins Proteom,2009,1794(8) :1211 -1217.
  • 6YANAGIS,INATOMER,TAKANOT,etai. Syk expression and novel function in a wide variety of tissues [J]. Biochem Biopharm Res Communj Ztlll'l , 288(3) :495 -498.
  • 7KLEINAU S, MARTINS SON P, HEYMAN B. Induction and suppression of collagen-induced arthritis is dependent on distinct Fcgamma receptors [J]. J Exp Med,2000,191(9) :1611-1666.
  • 8LI B-K, CONG Y, YANG X G, et al. In silico prediction of spleen tyrosine kinase inhibitors using machine learning approaches and an optimized molecular descriptor subset generated by recursive feature elimination method [J]. Comput BioI Med, 2013 ,43 (4) :395 -404.
  • 9MELTZER E O,BERKOWITZ R B,GROSSBARD E B. An intranasal Syk-kinase inhibitor (R112) improves the symptoms of seasonal allergic rhinitis in a park environment [J]. J Allergy Clin Immun, 2005 , 115(4) :791 -796.
  • 10PINE P R, CHANG B, SCHOETTLER N, et aI. Inflammation and bone erosion are suppressed in models of rheumatoid arthritis following treatment with a novel Syk inhibitor [J]. Clin Immunol, 2007 , 124 (3) :244 -257.

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