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呼吸衰竭患者外周血T淋巴细胞亚群的相关研究 被引量:5

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摘要 目的分析呼吸衰竭患者外周血T淋巴细胞亚群的特点、影响因素、临床意义及其治疗前后测定值的变化。方法采用免疫组织化学染色的方法测定100例呼吸衰竭患者CD3+、CD4+和CD8+细胞的阳性细胞百分率、CD4+/CD8+比值以及患者治疗前后外周血中T细胞亚群水平,并与正常对照组进行比较分析。结果呼吸衰竭患者外周血CD3+、CD4+明显减少,而CD8+明显增加,CD4+/CD8+比值明显下降,与正常组比较差异有统计学意义(P<0.01)。呼吸衰竭治疗后CD3+、CD4+细胞、CD4+/CD8+比值较前升高,差异有统计学意义(P<0.05)。结论呼吸衰竭患者存在细胞免疫功能紊乱,检测患者外周血T淋巴细胞亚群表达对评估患者的细胞免疫功能及疾病的诊断具有重要的临床意义。
机构地区 河北省胸科医院
出处 《河北医药》 CAS 2010年第9期1092-1093,共2页 Hebei Medical Journal
基金 河北省医学科学研究重点课题(编号:05403)
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