老年阻塞性睡眠呼吸暂停低通气综合征合并高血压的炎症机制研究

Inflammatory factors in senile patients with obstructive sleep apnea syndrome and hypertension

目的观察老年阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血中炎性因子浓度与OSAHS合并高血压的关系,揭示炎症因子在OSAHS合并高血压发病机制中的作用。方法病例对照研究,分为OSAHS组与OSAHS合并高血压组。通过多导睡眠图(PSG)明确诊断中重度OSAHS的老年男性患者80例,其中40例为OSAHS合并高血压患者。用ELISA法检测血清中TNF-α、hp-CRP浓度。结果 OSAHS合并高血压患者TNF-α、hp-CRP浓度水平均显著高于无高血压的OSAHS组患者,两组间差异有统计学意义(P<0.05)。结论炎性因子在OSAHS并发高血压的发生、发展过程中可能具有重要作用。

Objective To study the inflammatory factors in the senile patients with moderate or severe obstructive sleep apnea syndrome（OSAHS） and hypertension.Methods Eighty elderly patients（〉60year） were divided into OSAHS group（n=40） and OSAHS with hypertension group（n=40） by the results of polysomnogram（PSG）.The serum levels of TNF-α and hp-CRP were measured by ELISA.Results The serum levels of TNF-α and hp-CRP in OSAHS with hypertension group were higher than those of OSAHS group（P〈0.05）.Conclusion The inflammatory factors level are different between OSAHS patients with hypertension and without,which may play a role in the development of hypertension in OSAHS patients.