曲美他嗪对舒张性心力衰竭的疗效评价

Therapeutic effect of trimetazidine on diastolic heart failure

目的观察曲美他嗪对舒张性心力衰竭患者血浆脑钠肽水平及左室舒张功能的影响。方法舒张性心力衰竭患者60例,心功能Ⅱ-Ⅲ级,左心室射血分数（EF）大于或等于50%,随机分为曲美他嗪组（30例）和标准治疗组（30例）,标准治疗组采用常规抗舒张性心力衰竭治疗方法,曲美他嗪组在常规抗舒张性心力衰竭治疗基础上加用曲美他嗪治疗,两组患者观察治疗6个月,每组患者分别进行治疗前、后血浆脑钠肽及左室舒张功能的测定。结果曲美他嗪组和标准治疗组均能降低血浆脑钠肽水平,与标准治疗组相比,曲美他嗪组下降更明显,差异有统计学意义（P〈0.01）;与标准治疗组相比,曲美他嗪组能更有效地改善左室舒张功能（P〈0.01）。结论在常规治疗舒张性心力衰竭的基础上,加用曲美他嗪能显著降低血浆脑钠肽的水平,从而改善患者的左室舒张功能。

Objective To observe the effect of trimetazidine on plasma brain natriuretic peptide levels and diastolic function of Ventriculus sinister in the patients with diastolic heart failure.Methods A total of 60 patients with heart function class Ⅱ-Ⅲ and EF≥50%,were randomly divided into TMZ group and standard treatment group.standard treatment group received routine medications,while TMZ group received TMZ and routine medications for 6 months.The BNP levels and diastolic function of Ventriculus sinister were determined before and after therapy.Results Plasma brain natriuretic peptide levels were lower in the two groups.Compared with the standard treatment group,trimetazidine improved diastolic function of Ventriculus sinister and reduced the level of plasma BNP significantly.Conclusion In the basis of the standard treatment on diastolic heart failure,plus TMZ cansignificantly reduce BNP levels,and improve the diastolic function of Ventriculus sinister.