胃泌素和胃泌素受体与大肠癌的关系

Study of the levels of gastrin in serum and gastrin receptor in colrectal tissue in patients with colorectal cancer

目的探讨胃泌素和胃泌素受体与大肠癌的关系。方法采用ＲＩＡ测定大肠癌患者（ｎ＝３０）、良性疾病患者（ｎ＝２０）手术前后和正常人（ｎ＝２２）血清胃泌素含量；用免疫组化检测大肠癌组织、癌旁组织及远癌组织中胃泌素受体的表达。结果①大肠癌患者术前血清胃泌素水平显著升高，术后２周基本恢复正常（Ｐ＜０．０５）；②癌组织和癌旁组织中胃泌素受体阳性率高于远癌组织（Ｐ＜０．０５）。结论胃泌素可作为大肠癌诊断与预后判断的参考指标，癌旁组织虽无组织形态学改变，但胃泌素受体阳性率高，暗示此处组织可能已处于癌前状态。

Objective To investigate the relation of the Gastrin in serum and Gastrin Receptor (GR) in colorectal tissue in patients with colorectal cancer (CRC). Methods The serum levels of Gastrin were measured by using RIA and the expression of GR in carcinoma tissue, paracarcinoma tissue and out carcinoma tissue were detected with immunohistochemical techniques in 30 patients with CRC and 20 patients with benign diseases before and after operation, and 22 normal adults as a control group. Results ① The serum levels of Gastrin in patients with CRC were significantly increased before operation than that in the control group, but decreased to normal levels two weeks after operation ( P <0.05); ② The expression of GR in carcinoma tissue and para carcinoma tissue was significantly higher than that in out carcinoma tissue ( P <0.05). Conculsions The serum levels of Gastrin may be useful in the diagnosis and for judging the prognosis in patients with CRC. Althoug the morphology on microscopy is normal in para carcinoma tissue, the expression of GR is high. It may indicate that paracarcinoma tissue has a precarcinmatous statue, so it is reasonable that the distal resection margin from the rectal cancer should be equal or more than 3cm, if possible.