人工麝香对退变颈椎间盘中免疫球蛋白的含量影响

Synthetic Moschus' Role to Imminoglobulin Content in Degenerated Cervical discs

方法：实验选用15只新西兰兔，分为3组，每组5只，分别为颈椎间盘退变组、颈椎间盘退变加人工麝香饲养组和正常对照组。通过切除动物颈棘上及棘间韧带和分离颈椎旁两侧肌肉，造成颈椎力学上的失衡而诱导了兔的颈椎间盘退行性变化。在术后8月时，杀死动物．取动物颈椎间盘组织，用单向环状免疫扩散技术测定其中IgG及IgM含量。结果：退变颈椎间盘中IgG含量明显升高；人工麝香具有显著降低退变颈椎间盘中IgG的作用，IgM与颈椎间盘退变无关。

Methods: In this study, 15 white Newzealand rabbits were used and seperated into three groups: degenerated cervical disc group,degenerated cervical disc group with Synthetic Moschus,and control group,and each group has five rabbits. The experimental model of degenerated cervical disc in the rabbit was established by resection of cervical supraspinous and interspinous ligaments and detachment of posterior paravertebral muscles from the cervical vertabrae. Rabbits were killed eight months after operation. The cervical disc tissues in all three groups were assayed to detect IgG and IgM content by simple agar diffusion method. Results: The results were showed that the IgG content in degenerated cervical discs were obviously higher than those of control discs; synthetic Moschus could obviously decrease IgG content in degenerated cervical disc; IgM were not related to disc degeneration.