参麦注射液在腹部外伤低血容量性休克致多脏器功能失常综合征中的防治作用

The preventive effect of Shenmai Injection on multiple organ dysfunction syndrome caused by abdominal injury complicating hypovolemic shock

目的：探讨参麦注射液对腹部外伤并发低血容量性休克所致多脏器功能失常综合征（ＭＯＤＳ）的防治作用。方法：腹部外伤低血容量性休克患者６８例，随机分成２组。对照组３２例，采用手术及综合治疗；治疗组３６例，在手术及综合治疗基础上于休克发生后２４小时内加用参麦注射液静滴，每日１次。观察创伤后不同时间ＭＯＤＳ发生数和死亡数。结果：创伤后３日，治疗组ＭＯＤＳ发生数和死亡数与对照组比较无显著性差异（Ｐ＞０．０５），创伤后第５、７、１１、１５日治疗组的ＭＯＤＳ发生数和死亡数与对照组比较均有显著性差异（Ｐ＜０．０５和Ｐ＜０．０１）。结论：参麦注射液有扩张血管、改善微循环和调节免疫功能的作用。创伤发生后早期连续应用参麦注射液对腹部外伤并发低血容量性休克所致的ＭＯＤＳ具有预防作用。

Objective:To investigate the preventive effects of Shenmai Injection on multiple organ dysfunction syndrome (MODS) caused by abdominal injury complicating hypovolemic shock.Methods: 68 cases with abdominal injury complicating hypovolemic shock were randomly divided into two groups.The control group ( n =32 ) was treated with operation and general therapy.On the basis of operation and general therapy the treatment group ( n =36) was treated with Shenmai Injection infused intravenously once a day as a additional within 24 hours after occurance of shock.The morbidity and mortality of MODS at the different time after accurance of abdominal injury were observed.Results:On the third day after trauma,the morbidity and motality in treatment group were not significantly different from those in control group (all P >0 05).However,on the fifth,seventh,eleventh and fifteenth day were of significant difference ( P <0 05 or P <0 01).Conclusions:Shenmai Injection has the actions of dilating vessels,improving microcirculation and regulating immunologic functions.If constantly used early after trauma,Shenmai Injection has the preventive effects on MODS caused by abdominal injury complicating hypovolemic shock.