尿激酶静脉溶栓治疗急性进展性脑梗死对血液流变学的影响和疗效判断

The Influence and Efficacy about Intravenous Thrombolytic Therapy for Acute Cerebral Infarction on Hemorheology by Urokinase

目的观察尿激酶(UK)静脉溶栓治疗急性进展性脑梗死的疗效及对血液流变学的影响。方法对发病在6～24h以内的急性进展性脑梗死72例患者随机分为3组,其中发病6～12h以内20例为治疗A组,发病12～24h内22例为治疗B组,和对照组(C组30例),两治疗组均应用尿激酶100万～200万U静脉滴注之后应用常规治疗,对照组应用常规治疗。结果治疗组采用的尿激酶静脉溶栓总有效率、神经功能缺损恢复的程度上、血液流变性的改善均明显优于对照组(P<0.05),但两治疗组间无显著差异(P>0.05)。结论尿激酶静脉溶栓治疗发病6～24h以内的无溶栓禁忌证的急性进展性脑梗死是安全、有效的,能显著改变血液流变性。

Objective To observe the effect about urokinase（UK） thrombolytic therapy in acute cerebral infarction and the influence on hemorheology.Methods Within the 6 ～ 24h 72 cases of acute cerebral infarction were randomly divided into 3 groups,the incidence of which 20 cases within 6 ～ 12h for treatment A group,incidence of 12 ～ 24h in 22 cases for the treatment of B group,and control group（C group,30 cases）,the two treatment groups were urokinase 1,000,000 ～ 2,000,000 U intravenous drip after the application of conventional treatment,the control group received conventional therapy.Results The treatment group used the total effective intravenous thrombolysis,the degree of neurological deficit on the resumption,the improvement of blood rheology was significantly better than the control group（P0.05）,but the two treatment groups no significant difference（P0.05）.Conclusion Urokinase intravenous thrombolysis within 6 ～ 24h no contraindications thrombolysis on acute cerebral infarction is safe,effective,and can significantly change blood rheology.