川芎嗪注射液对急性颅脑损伤患者血液流变性的影响

The influences of tetramethylpyrazine injection on hemorrheology in patients with acute craniocerebral injury

目的：探讨颅脑损伤患者的有效治疗方法及观察川芎嗪注射液对患者血液流变性的影响。方法：将６０例患者随机分为Ａ组和Ｂ组（各３０例），并以２０例健康体检者为正常对照组。２组患者常规治疗相同，Ａ组加用川芎嗪注射液８０ｍｇ加入５％葡萄糖５００ｍｌ静滴，每日１次；Ｂ组单纯用５％葡萄糖５００ｍｌ静滴，每日１次，２组均连用７日。观察血液粘度（ηｂ）、红细胞压积（Ｈｃｔ）、血浆纤维蛋白原（Ｆｉ）、红细胞变形系数（ＴＫ）和微循环滞留时间（ＭＳＴ）等指标。结果：Ａ组与Ｂ组治疗后上述血液流变学指标均有显著性差异（Ｐ＜０．００１及Ｐ＜０．０５）。川芎嗪注射液用药前与用药后３日和７日比较，血液流变学指标除Ｈｃｔ外均有显著性差异（Ｐ均＜０．００１）。结论：急性颅脑损伤患者血液粘度增高；川芎嗪注射液可提高红细胞变形能力，降低血液粘度，对改善脑组织缺血缺氧和减轻脑水肿。

Objective:To investigate the effectively therapeutic method for craniocerebral injury and observe the influences of tetramethylpyrazine injection on patient hemorrheology.Methods:60 cases were randomly divided into group A and B( n =30,each group),and healthy persons ( n =20) as control group.Besides the same conventional treatment in both A and B group ,tetramethylpyrazine injection 80 mg diluted into 5% glucose 500 ml was infused intravenously to A group,but 5%glucose 500 ml only intravenously to B group,once a day for 7 days.The hemorrheologic parameters,including ηb,Hct,Fi,TK, and MST were observed. Results :On the third and seventh day before and after using tetramethylpyrazine injection,all the hemorrheologic parameters except for Hct shown markedly different (all P <0 001) between A and B group. Conclusions :The blood viscosity is increased in patients with acute cerebral injury;tetramethylpyrazine injection can elevate erythrocyte deformability,lower blood viscosity,and improve the ischemia and edema of cerebral tissue and have related curative actions.