血脂平冲剂对HLP大鼠补体调节蛋白CD55、CD59表达的影响

The Effect of XueZhiPing Granules on HLP Rat Complement Regulatory Proteins CD55,CD59 Expression

目的:揭示血脂平冲剂对实验性高脂血症大鼠CD55、CD59表达的影响。方法:将60只昆明种雄性SD大鼠随机分为六组:空白对照组、病理模型组、西药组、血脂平冲剂大剂量组、血脂平冲剂中剂量组、血脂平冲剂小剂量组。测定各组大鼠血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)的水平,流式细胞仪测定各组大鼠白细胞CD55、CD59表达的变化。结果:血脂平冲剂组大鼠TC、TG、LDL-C水平明显低于模型组(P<0.05),白细胞CD55、CD59的表达明显上调,且具有明显的量效关系。结论:血脂平冲剂具有明显的降脂作用,其机制可能与其促进CD55、CD59的表达上调有关。

Objective：To reveal XueZhiPing granules on HLP experimental rat CD55, CD59 expression. Methods：60 male SD Kunming rats were divided into six groups, control group, model group, comparision group, XueZhiPing granules high-dose group, XueZhiPing granules middle-dose group, XueZhiPing granules low-dose group. Measured serum total cholesterol （TC）, triglyceride （TG）, high density lipoprotein cholesterol （HDL-C）, low density lipoprotein cholesterol （LDL-C） levels. Rats CD55, CD59 expression changes measured by flow cytometry leukocyte. Results：XueZhiPing granules groups TC, TG, LDL-C levels were significantly lower than model group （P 〈0.05）, leukocyte CD55, CD59 is upregnlated, and has significant dose-effect relationship. Conclusion：XueZhiPing granules have obvious lipid-lowering effect and the mechanism may be related to the promotion of CD55, CD59 upregulation.