斯奇康联合糖皮质激素对初治原发性肾病综合症患儿疗效观察

Effects of BCG-PSN Combined with Glucocorticoids on Children Diagnosed with Primary Nephrotic Syndrome

目的观察糖皮质激素联合斯奇康对初治原发性肾病综合症患儿缓解率和复发率的影响.方法将我院确诊的108例初发肾病综合症病人随机分为对照组和治疗组.对照组病例给予足量泼尼松治疗,治疗组病人在对照组病人治疗方案基础上给予斯奇康肌肉注射.记录两组病人缓解率和复发率.结果两组病人在随访1个月后缓解率无明显差别,随访2月、6月时,治疗组患者缓解率较对照组升高.治疗2月后,治疗组血清IgG、IgA、IgM显著增高(P<0.05).随访1 a,与对照组相比,治疗组肾病综合症复发人次数显著减少,缓解率增加.结论糖皮质激素联合卡介苗多糖核酸治疗肾病综合症,可以提高缓解率,减少复发率.表3,参15.

Objective To observe the effects of BCG - PSN combined with glucocorticoids on remission rate and relapse rate in children newly diagnosed with primary nephrotic syndrome. Methods 108 patients with primary nephrotic syndrome in our hospital were divided into control group and treatment group. The children in control group were given prednisone therapy. And the chilren in the treatment group were given BCG - PSN intramuscular injection besides all the treatments for patients in the control group. The remission rate and relapse rate were recorded. Results There was not significant diffenrence in the remission rate between the two groups after 1 month follow -up. A higher remission rate was found in patients from the treatment group at the 2nd and 6th month during the follow up. 2 months later after treatment, serum IgG, IgA, IgM in treatment group were higher than that in the control group （P 〈 0.05）. Compared with that in the control group, patients in the treatment group showed a higher remission rate and decreased relapse rate after 1 year follow - up. Conclusion Glucocorticoid therapy combined with BCG - PSN can improve remission rates and reduce relapse rates in patients with primary nephrotic syndrome. 3tabs. , 15refs.