摘要
胃泰胶囊对免疫及理化攻击等综合法所致的大鼠萎缩性胃炎模型有良好的治疗作用，动物一般状况改善，胃酸及消化酶活性升高，胃粘膜萎缩病变及炎症改善；并使水杨酸性胃炎病变减轻。对小鼠胃肠推进运动无影响；抑制二甲苯致小鼠耳壳肿胀及皮下棉球肉芽肿的增生，抑制醋酸引起的小鼠扭体反应，对热板法致痛无影响；增加大鼠的红细胞Ｃ３ｂ受体花环率、淋巴细胞转化率和小鼠吞噬细胞的功能，升高血清ＩｇＧ水平。主题词：＠胃泰胶囊／药理学；萎缩性胃炎／中药疗法；
Weitai Capsule(WC) has the therapeutic effects on atrophic gastritis induced by immune reaction and physiochemical factors in model rats. After administration of WC the general condition of rats was improved, the activities of gastric acid and digestive enzyme increased and the atrophic changes of gastric mucosa and gastritis induced by salicylic acid were also alleviated. WC had no effects on the rabbit intestinal and the mouse gastrointestinal peristalsis in vivo. The xylene_induced auricular swelling and the cotton_ball_induced subcutaneous granulation hyperplasia in mice were inhibited. The body torsion induced by acetic acid was reduced, but pain induced by hot plate was not relieved. The results revealed that WC can increase the rosette forming rate of C3b_receptor of red blood cell and lymphocyte transformation rate in the rat,improve the function of phagocytes and increase the level of serum IgG in mice.
出处
《中药新药与临床药理》
CAS
CSCD
1999年第1期21-23,共3页
Traditional Chinese Drug Research and Clinical Pharmacology
关键词
胃泰胶囊
药理学
萎缩性胃炎
中医药疗法
Weitai Capsule/pharmacol.
Gastritis,atrophic/TCD ther.
Animal disease model
