葛根素衍生物纳米粒的制备及形成机制探讨

Preparation and Drug-loaded Mechanism of Puerarin Derivatives Nanoparticles

目的制备葛根素衍生物4ac纳米粒,探讨其形成机制。方法采用热力学参数差示扫描量热分析(DSC)、X-射线粉末衍射及红外光谱法,鉴定葛根素衍生物4ac纳米粒形成过程中药物与辅料之间的相互作用。结果药物与辅料之间无相互作用,药物主要是以包埋的形式存在于载体中,此外也有少量的药物吸附于载体的表面。结论纳米粒的形成过程为物理结合,未发生化学反应。

Objective To study the preparation of puerarin derivatives 4ac nanoparticles and its drug- loaded mechanism.Methods Puerarin derivatives nanoparticles were prepared according to the method of solvent evaporation technique,and the interaction between the drug and the carrier in the process of preparation was identifi ed by the means of DSC、X-ray and Infrared-sepectrometry.Results There is no interaction between the drug and the adjuvant.The drug mainly embedded in the carrier,and also there is little drug was absorbed on the surface of the carrier.Conclusion The process of nanoparticles preparation is physical mixture ,it had not the chemical reaction.