维汉民族精神疾病患者事件相关电位视觉P300对照研究

Comparative studies on visual event related potential P300 of Han and Uygur patients with mental disorder

目的:探讨维汉两民族精神分裂症、抑郁症、焦虑症患者事件相关电位视觉P300的临床应用价值及特点。方法:141例精神分裂症患者(精神分裂症组)、147例抑郁症患者(抑郁症组)、146例焦虑症患者(焦虑症组)和120名健康志愿者(对照组),采用BrainMaster脑诱发电位系统进行视觉P300检测。结果:精神分裂症组P300各指标与对照组比较差异均有统计学意义(P<0.05);抑郁症组除P2潜伏期外、焦虑症组除N1潜伏期外,其余各指标与对照组差异均有统计学意义(P<0.05或P<0.01)。维汉两民族P300各指标间差异均无统计学意义(P>0.05)。结论:视觉P300能比较客观地反映精神疾病患者的认知功能,亦可用于维族人群。

Objective：To investigate the features and clinical application of brain evoked potentials（BEP）in patients with schizophrenia（SCh）,depression（CD）or anxiety（AD）.Method：A total of 141 patient with schizophrenia,147 patients with depression,146 patients with anxiety and 120 normal controls were involved.all the 4 groups were examined potential P300 using Brain Master instrument.Results：Schizophrenia group showed significant differences on all P300 indices from control group;depression group on all P300 indices except P2;anxiety group on all P300 indices except N1（P〈0.01 or P〈0.05）.There were no significant difference in all of the data between Uygur and Han people（P〈0.05）.Conclusion：P300 can be representation of the cognitive function of patients with mental disorders,and be applied to both Uyghur and Han people.