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肝胆通对胆结石豚鼠体内胃肠激素水平的影响 被引量:9

Effect of Gandantong on Motilin and Somatostatin in Guinea Pig with Gallstones
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摘要 目的:探讨肝胆通临床治疗机制。方法:采用放射免疫分析法(RIA)测定豚鼠体内门静脉血浆及胆囊壁组织内胃动素(MTL)、生长抑素(SS)的含量。比较正常对照组、胆石组、自然恢复组和肝胆通组体内水平。结果:胆石组体内门静脉血浆及胆囊壁组织中MTL含量均下降,而SS均增高;自然恢复组体内MTL、SS未能全部恢复正常;胆肝通组体内两种激素不仅全部恢复正常,而且与对照组比较,MTL增高,SS下降。结论:肝胆通具有调节胆结石豚鼠体内MTL、SS等胃肠激素的作用,其临床效果与此有关。 Objective:To evaluate the clinical therapeutic mechanism of Gandantong.Methods:Motilin(MTL)and somatostatin(SS)in the blood of the portal vein and gallbladder tissue from guinea pigs were measured with radioimmunoassay.The levels of these two gut peptides from the control group(20 animals),lithogenie group(30 animals),recovering group(15 animals)and Gandantong group(15 animals)were compared.Results:MTL concentration decreased,but SS increased in specimens taken from the portal vein plasma and the gallbladder tissue in the lithogenic group.The levels of MTL and SS in the recovering group did not return satisfactorily to normal.In the Gandantong group,the levels of MTL were higher,but SS lower than those in the control group.Conclusion:Gandantong could increase the MTL levels and decrease SS in guinea pigs with gallstones,which might be related to its clinical therapeutic mechanism.
出处 《中国中西医结合外科杂志》 CAS 1999年第1期47-49,共3页 Chinese Journal of Surgery of Integrated Traditional and Western Medicine
基金 国家自然科学基金 江西省自然科学基金
关键词 胃动素 生长抑素 胆结石 肝胆通 中医药疗法 Chinese herbal medicine,motilin,somatostatin,gallstones,animal study
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