HCG日血清孕酮平对IVF-ET结局的影响

Effect of serum progesterone on the day of human chorionic gonadotrophin administration on clinical outcome in IVF-ET

目的:探讨体外受精-胚胎移植(IVF-ET)患者注射人绒毛膜促性腺激素(HCG)日血清孕酮(P)水平对IVF-ET妊娠结局的影响。方法:回顾性分析我中心2008～2009年经过IVF-ET治疗后行胚胎移植术的患者1416个周期的临床资料。根据注射HCG日血清P水平,分为P<2ng/ml(A组),2ng/ml≤P<3ng/ml(B组),P≥3ng/ml(C组),比较各组患者年龄、不孕年限、内膜厚度、窦卵泡数、获卵数、胚胎数、优胚数、移植胚胎数、种植率和临床妊娠率。结果:各组患者年龄、不孕年限、内膜厚度、窦卵泡数、获卵数、胚胎数、优胚数、移植胚胎数均无显著性差异。A组种植率为27.81%、临床妊娠率为42.89%;B组种植率为22.36%、临床妊娠率为36.48%;C组种植率为15.96%、临床妊娠率为27.27%,各组比较有显著性差异。结论:IVF-ET中,注射HCG日血清P水平升高可引起临床妊娠率和种植率的下降。

Objective：To evaluate the effect of serum progesterone on the day of human chorionic gonadotrophin administration on clinical outcome in IVF-ET. Methods：1 416 cycles of infertile patients undergoing IVF-ET from January 2008 to December 2009 were reviewed. The cycles were divided into three groups according to serum progesterone levels on the day of HCG administra-tion：P〈2 ng/ml（group A） ,2 ng/ml≤P〈3 ng/ml（group B） ,P≥3 ng/ml（group C） . Then compared their age,infertility duration,thick of endometrium,follicle numbers,the number of oocytes,embryos,ET embryos,implantation rate and pregnancy rate. Results：Their age,infertility duration,thick of endometrium,follicle numbers,the number of oocytes,embryos,ET embryos were no significant difference in all groups. Implantation rates were 27.81%,22.36% and 15.96% respectively and pregnancy rates were 42.89%,36.48% and 27.27%,the differences were statistically significant. Conclusion：Implantation rate and pregnancy rate significantly decrease when serum progesterone levels on the day of HCG administration increase.