56例新生儿败血症病原学及药敏结果分析

Distribution and antibiotic susceptibility of pathogens isolated in 56 cases of neonatal septicemia.

目的了解近年新生儿败血症病原学分布及药物敏感状况，以指导临床治疗。方法对2000年1月-2007年1月住院的经血培养证实阳性的56例新生儿败血症患儿的血培养检出菌和药敏实验结果进行回顾性分析。结果凝固酶阴性葡萄球菌为主要病原菌33株（58．9％），金黄色葡萄球菌6株（10．7％），大肠埃希菌7株（12．5％），肺炎克雷伯杆菌4株（7．2％）；病原菌对青霉素、氨苄青霉素、红霉素耐药率高，万古霉素、亚胺培南、环丙沙星耐药率低。结论引起新生儿败血症的主要致病菌为凝固酶阴性葡萄球菌，临床应根据血培养药敏结果选用敏感抗菌药物，以减少病原菌耐药性的产生，提高治疗效果。

Objective To investigate pathogens in neonatal septicemia and the antimicrobial resistance of these bacteria to guide the clinical treatment. Methods The data of 56 neonatal septicemia confirmed by hemoculture from Jan 2001 to Jan 2007 in our hospital were analyzed by retrospectively. Results Coagulase -negative Staphylococcus were the main pathogens, occuping 58.9% ,staphylococcus aureus occu- pied 10. 7%. Their were 12. 5% of Escherichia coli, and 7.2% of Klebsiella pneumoniae. Bacteria were highly resistant to penicillin, ampicillin and erythrocin. But vancomycin,imipenem and ciprofloxacin were the most sensitive drugs. Conclusion Coagulase - negative Staphylococcus are main pathogens in neonatal septicemia. To choose sensitive antibiotics bases on the drug sensitivity tests may decrease the occurrence of drug re- sistance to bacteria and increase the clinical curative effects.