米非司酮配伍米索前列醇终止中期妊娠的临床效果

To investigate clinical effect of mifepristone combined with misoprostol on middle gestation.

目的探讨米非司酮配伍米索前列醇终止中期妊娠的临床效果，为今后临床中期妊娠提供科学依据。方法回顾性分析笔者所在医院2006年11月～2008年11月89例要求终止妊娠者（孕13～24周）的临床资料，根据其用药方法分为实验组和对照组，实验组采用米非司酮片150mg顿服，第3日晨米索前列醇片0．4mg阴道后穹窿放置，对照组采用利凡诺针100mg羊膜腔内注射，观察两组的临床效果。结果实验组和对照组引产成功率分别为100％和84．1％，实验组比对照组产后出血量少、清官率低、流产时间短、宫缩痛轻，两组比较差异具有统计学意义（P〈0．05）。结论米非司酮配伍米索前列醇终止中期妊娠的临床效果显著．是一种相对安全、有效的引产方法。

Objective To investigate the medium - term pregnancy with mifepristone and misoprostol to terminate the clinical effects for the future to provide a scientific basis for the clinical mid - term pregnancy. Methods Retrospective analysis of our hospital in November 2006 - 2008 years in November to terminate the pregnancy in 89 cases （13 -24 weeks pregnant） and clinical data, based on their medication meth- ods were divided into experimental group and control group, experimental group non -Secretary Tablets 150rag Burton suits, the first on the 3rd morning ＇after the misoprosto] tablets 0.4 mg vaginal fornix placement, control group Rivanol 100 mg amniotic needle injection, clinical effects were observed. Results In the experimental group and the control group the success rate of labor induction were 100% and 84. 1% , experimen- tal group less than the control group, postpartum hemorrhage, the Cleaning Uterus rate is low, miscarriage a short time, uterine pain, light; difference between the two groups was statistically significant （ P 〈 0. 05 ）. Conclusion Mifepristone and Misoprostol for termination of the clin- ical effects of the medium - term pregnancy significantly, is a relatively safe and effective method of induction of labor.