基于色氨酸的生物受体合成与阳离子识别研究

Synthesis of tryptophan-based receptors and their cation recognition properties

以胺羧配体EDTA、DTPA作为二价模板框架,利用简便方法设计合成了以色氨酸为核心识别单元、含有苯丙氨酸的开链式结构生物受体,并利用荧光光谱和质谱等技术研究了受体与碱土金属离子(Ca2+、Ba2+、Mg2+)和过渡金属离子(Cu2+、Fe2+、Co2+、Ni2+、Mn2+、Zn2+、Cd2+)以及碱金属离子(Li+、Na+、K+)之间的相互作用.结果发现,在水溶液中金属离子与吲哚环之间存在相互作用,这两个受体对多种具有重要生物学和环境保护意义的金属离子有着良好的选择性识别作用.

This work is to investigate the interaction between metal ions（Ca^2＋,Ba^2＋,Mg^2＋,Cu^2＋,Fe^2＋,Co^2＋,Ni^2＋,Mn^2＋,Zn^2＋,Cd^2＋,Li^＋,Na^＋and K^＋） and receptors,which were prepared by using available multidentate amino-carboxylate,EDTA and DTPA,as divalent template for presenting peptidyl Trp indole and Phe benzene.A combined ESI-MS and fluorescence spectroscopic study reveals the roles of metal ion-indole interactions.It was found that the two receptors were excellent metalloreceptor models with high sensitivity and remarkable selectivity for biologically or environmentally important metal ions in water.