Plasma brain natriuretic peptide and atria natriuretic peptide as predictors for diastolic heart failure in patients with type 2 diabetes mellitus

在糖尿病的病人学习心脏舒张的心脏的功能的变化并且与类型 2 糖尿病 mellitus.Methods 在病人为心脏舒张的心失败决定血浆大脑 natriuretic 肽( BNP )和正厅 natriuretic 肽( ANP )的诊断价值的目的 12 个健康题目和 71 个糖尿病的病人在 study.Plasma 被包括 BNP 和 ANP 与 ofBNP andANP 与 dias 的增加的严厉显著地增加了的 immunoradiometic assay.Results

Objective To study the change of diastolic cardiac function in diabetic patients and to determine the diagnostic value of plasma brain natriuretic peptide （BNP） and atria natriuretic peptide （ANP） for diastolic heart failure in patients with type 2 diabetes mellitus. Methods Twelve healthy subjects and seventy-one diabetic patients were included in the study. Plasma BNP and ANP were measured with immtmoradiometic assay. Results Plasma levels of BNP and ANP increased significantly with increased severity of diastolic heart dysfunction. The ratio of E/A had significant negative correlation with the plasma levels ofBNP （r=0.669,P〈0.001） and ANP （r=0.579, P〈0.01）. AUC of ANP and BNP in ROC model was 91.9% and 65.3%, respectively. Conclusions The plasma level of BNP might be a valuable predictor for differential diagnosis of diastolic cardiac function in diabetic patients.