急性心肌梗死患者血浆凝血因子Ⅶ和抗凝血酶Ⅲ的变化及其意义

Changes and clinical significane of plasma coagulation factor Ⅶ and antithrombin III in patients with acute myocardial infarction

目的 探讨急性心肌梗死（AMI）患者血浆凝血因子/Ⅶ、抗凝血酶Ⅲ（AT-Ⅲ）活性的变化及其意义.方法 对40例AMI患者血浆FVIIag含量、FVIIa水平、FVII;C及AT-Ⅲ水平进行检测,并与20名健康人进行比较,分析其变化,并探讨其在急性心血管事件中的意义.结果 AMI患者血浆FVIIag含量、FVIIa水平及FVII：C高于（P〈0.05或P〈0.01）,且FVIIa水平升高更显著,而血浆AT-Ⅲ活性显著低于健康对照组（P〈0.01）.结论 血浆凝血因子Ⅶ和AT-Ⅲ参与AMI时的凝血过程,血浆活化凝血因子Ⅶ增高及AT-Ⅲ活性降低可能是急性心血管事件敏感预测指标.

Objective To observe changes of plasma coagulation factor Ⅶ（FVII） and antithrombin III（ AT-Ⅲ） in patients with acute myacardial infarction（AMI） . Methods The blood samples of 40 patients with AMI and 20 healthy volunteers were obtained through vein at the moment of admission. The plasma activated factors（ FVIIag,FVI- la,FVII： C and AT-Ⅲ） were detected with different methods. Results Compared with control group,the plasina levels of FVIIag, FVIIa and the FVII： C in patients with AMI were significantly higher（ P 〈 0.05, P 〈 0. 01） and especially in FVIIa（P 〈0.01） ,the AT-Ⅲ activity decreased significantly. Conclusion FVIIa and AT-III play important role in thrombosis of AMI,and the changes of their activities could predict the formation of acute cardiovascular event.