高危型人乳头状瘤病毒与男性膀胱移行细胞癌的相关性

Relationship between high-risk HPV infection and transitional cell carcinoma of bladder in male

【目的】探讨高危型人乳头状瘤病毒感染与膀胱移行细胞癌发病之间的相关性,并分析其与膀胱癌分级和分期之间的关系。【方法】收集2008年9月至2009年8月期间,在我院就诊的膀胱移行细胞癌患者的肿瘤组织56例(病例组)和正常膀胱组织21例(对照组),采用第2代杂交捕获技术检测各标本高危型HPVDNA。【结果】病例组和对照组中,HPV感染率分别为62.5%(35/56)和4.1%(1/21),病例组与对照组中HPVDNA感染率差异有统计学意义(χ2=20.45,P<0.001)。病例组中不同病理分级和临床分期的膀胱移行细胞癌患者HPV感染率相比差异有统计学意义(χ2值分别为9.91和4.43;P值分别为0.007和0.035)。【结论】高危型HPV感染与膀胱移行细胞癌的发生有一定相关性,且可能在膀胱癌形成的早期阶段起的作用更大。高危型HPV感染有可能成为膀胱移行细胞癌早诊早治的有效生物学指标之一。

[Objective] To explore the link between high-risk HPV infection and risk of transitional cell carcinoma of bladder in male and analyze the correlation between HPV infection and tumor grading and staging. [Methods] 56 cases of male transitional cell carcinoma tissues of bladder were collected from 2008.09 to 2009.08, and 21 normal bladder tissues as control. Hybrid Capture 2 was used to detect High-risk HPV DNA. [Results] The prevalence of HPV were 62.5% （35/56） and 4.8% （1/21） in diseased tissue and control respectively （χ2=20.45,P 0.001）. HPV infection was correlated with differentiation（χ2=9.91;P = 0.007） and clinical stage （χ2= 4.43;P = 0.035）significantly. [Conclusions] High-risk HPV infection was correlated with transitional cell carcinoma of bladder in male and plays more role in the early stage of the development of transitional cell carcinoma probably. High-risk HPV detection may be helpful in the early detection and treatment of male transitional cell carcinoma of bladder and maybe one of the effective biomarkers.