半导体激光照射配合重组人IL-2治疗复发性生殖器疱疹

Treatment of recurrent genital herpes by recombinant human interleukin-2 with semiconductor laser irradiation

【目的】研究半导体激光照射骶神经节配合重组人IL-2治疗复发性生殖器疱疹的临床疗效及复发率。【方法】将160例确诊的复发生殖器疱疹患者随机分为2组,每组各80例。对照组仅口服伐昔洛韦。治疗组在此基础上加用半导体激光照射骶神经节配合重组人IL-2。【结果】治疗组痊愈率和总有效率均显著高于对照组(P<0.01),而复发率显著低于对照组(P<0.01)。【结论】在常规抗病毒的基础上,加用半导体激光照射骶神经节配合重组人IL-2治疗复发性生殖器疱疹,具有较好的临床疗效,并能明显降低复发率,值得临床进一步研究探讨。

[Objective] To study the recurrent rate and the clinical effect of treating genital herpes recurrencts by Recombinant human interleukin-2（IL-2） with semiconductor laser irradiating sacral ganglion. [Methods] 160 patients diagnosed as recurrenct genital herpes were randomly divided into experimental group （n = 80） and control group （n = 80）.The control group received treatment of valaciclovir hydrochloride tablets. The experimental group received recombinant IL-2 and valaciclovir hydrochloride tablets with Semiconductor laser irradiating sacral ganglion. [Results] The total effective rate and cure rate in experimental group was significantly higher than that in control group （P 0.01）. But there was a marked lower recurrent rate of genital herpes in experimental group （P 0.01）. [Conclusions] The further clinical study on the treatment of recurrenct genital herpes by recombinant IL-2 with semiconductor laser irradiating sacral ganglion is necessary since it can significantly decrease the recurrence rate and has a better clinical effect.