黄姜皂素清洁生产工艺研究

Research on Clean Production Process for Diosgenin

以乙醇为溶剂浸提黄姜干粉中的皂苷,通过水解、过滤、中和、洗涤、干燥、石油醚抽提、结晶、重结晶得到纯度较高的黄姜皂素。研究了间歇浸提工艺中溶剂体积分数及其用量、浸提温度、浸提时间和次数等对皂素收率的影响:以50 g黄姜干粉为原料,以250 mL体积分数95%的乙醇为溶剂,浸提温度为60℃,间歇浸提3次,浸提时间为2 h/1 h/0.5 h时,皂素收率可达2.45%。在该基础上,为提高浸提效率且便于连续化生产,也考察了在高压均质机中连续均质浸提的工艺过程,操作压力60 MPa时连续均质浸提可达到与间歇浸提同等效果。间歇浸提和连续均质浸提工艺的耗酸量和废水量仅为传统工艺的10%,皂素收率较传统工艺的1.6%提高了53%。

The dioscin was extracted from dry yam powder with alcohol in this experiment.After hydrolysis reaction,filtration,neutralization,washing,dehydration,extraction using petroleum ether and recrystallization,high purity diosgenin was obtained.Results of the intermittent extraction process show that after three time extraction for 2 h-1 h-0.5 h,the yield of diosgenin can reach 2.45%,using raw material powder with the weight of 50 g and the solvent of 95%（volume content） alcohol with the volume of 250 mL,at the temperature 60 ℃.The continuous homogeneous extraction process was also researched to increase the extraction efficiency and facilitate the continuous production.The research shows that the continuous homogeneous extraction at pressure 60 MPa can achieve an equal effect to the intermittent extraction.The acid consumption and the waste water of both intermittent extraction and the continuous homogeneous extraction decrease to 10% of the traditional process.The yield of diosgenin increases by 53%.