摘要
目的：探讨脓毒症患儿凝血与纤溶功能的变化及临床意义。方法：用0．109mmol/L枸橼酸钠抗凝的试管取血3mL，BC（麦瑞5500）血常规分析仪进行血小板计数；D-二聚体（DD）含量用ELISA法测定；凝血4项：凝血酶原时间（PTT）、凝血酶时间（TT）、活化部分凝血酶时间（APTT）、纤维蛋白原（FBG），均采用SysmexCA-510全自动血凝仪进行分析。结果：脓毒症忠儿与健康儿童的血浆D-二聚体（DD）的比较，有显著性差异，（P〈0．01）具有统计学意义。脓毒症患儿APTT，PT，TT，FBG与PLT与健康儿童相比差异均有统计学意义（P〈0．05）。脓毒症患儿中其生存组与死亡组相比。其阿、APTT和PLT有明显差异，具有统计学意义（P〈0．05）。结论：脓毒症患儿凝血系统紊乱普遍存在，动态监测DD、PLG对病情估计和预后判断有一定临床意义。
Objective To investigate the function of coagulation and fibrinolysis in children with sepsis, changes and clinical significance. Methods 0. 109mmol / L sodium citrate to take the blood test- tube 3 mL, Celhac CE routine blood analyzer platelet count; D -dimer （DD） levels measured by ELISA method; Coagulation 4： prothrombin time （PT）, thrombin time （TT）, activated partial thmmboplastin time （APTT）, fibrinogen （FBG）, are used Sysmex CA -510 automated coagulation instrument for analysis. The results of sepsis in children with healthy children, plasma D -dimer （DD） comparison, there are significant differences, （ P 〈0.01 ） with statistical significance. Sepsis in children with APTT, PT, TT, FBG and PLT compared with healthy children, differences were statistically significant （ P 〈0.05） o Children with sepsis, the survival group and death group compared to the PT, APTT and PLT significant differences statistically significant （ P 〈 0.05）. Conclusions blood coagulation disorders in children with sepsis, widespread, dynamic monitoring of DD, PLG and prognosis of the disease estimated to have some clinical significance.
