伽玛刀联合全脑放疗治疗脑转移瘤疗效分析

The curative effect analysis of gamma knife combined with whole brain metastasis radiation therapy

目的：评价伽玛刀联合全脑放疗在脑转移瘤治疗中的价值。方法：将85例患者随机分成2组，A纽：全脑放疗组（42例）B组：全脑放疗联合伽玛刀治疗组（43例）A组行全脑放疗TD30Gy／IOF，B组现行伽玛刀治疗：边缘剂量为18．5Gy，中心最大剂量为34—40Gy，再行全脑放疗TD30Gy／15F，分别对两组患者的MRI变化及近期疗效进行统计学分析。结果：两组患者均随访半年以上，B组局部控制率93．0％，一年生存率为65．1％。均优于第一组（P〈0．05）。结论：伽玛刀联合全脑放疗疗效优于单纯全脑放疗。

objective： To evaluate the gamma knife combined with whole brain metastasis radiation therapy for brain metastasis Methods： 85 patients were derided into whole brain radiation （ greupl ） and gamma knife combined with whole brain（ group 2）, the greupl received only the whole metastasis total dose 30Gy for 10times, and the group 2 had radiation of 18.5Gy and a central dose of 34 -40Gy, followed by 30Gy/15 F, The MRI change and the short term curative effect were analyzed later. Results ： Two groups of patients were followed up for more than half a year, B group of local control rate of 93.0%, one - year survival rate was 65.1%, were better than the first group （ P 〈 0.05） Conclusions ： the ganuna knife combined with whale brain radiation therapy is better than whole brain radiation therapy alone.