抗体检测在类风湿性关节炎诊断中的应用

Antibody in rheumatoid arthritis diagnosis

目的：探讨抗体检测在类风湿性关节炎诊断中的应用价值和意义。方法：采用酶联免疫吸附法（E1ASA）检测anti—CCP，采用间接免疫荧光法检测AKA，采用速率散射比浊法检测RF。结果：anti—CCP、AKA与RF联合诊断类风湿性关节炎可以弥补RF对类风湿性关节炎诊断特异度低的缺点，减少假阳性率，而且在敏感度上也能提高对类风湿性关节炎的早期诊断。结论：抗体检测可作为类风湿性关节炎诊断的特异性血清学指标，可以提高类风湿关节炎的阳性诊断率，且有利于疾病的预后判断。

Objective： To investigate the antibody in rheumatoid arthritis diagnosis of the value and significance. METHODS ： Enzyme linked immtmosorbent assay （E1ASA） detected anti - CCP, by indirect immunofluorescence AKA, using rate nephelometry detection of RF. Results： anti - CCP, AKA and RF co - diagnosis of rheumatoid arthritis rheumatoid arthritis diagnosis of RF can make up for the shortcomings of low specificity and reduce the false positive rate, but also can increase the sensitivity to the class of rheumatoid arthritis Early diagnosis of inflammation. Conclusion： The antibody can be used as the diagnosis of rheumatoid arthritis - specific serum markers,Can increase the positive diagnosis of rheumatoid arthritis rates, and favorable prognosis of the disease.