摘要
目的：探讨奥氮平治疗难治性精神分裂症的临床疗效.方法：选取我院自2008年1月～2009年12月收治的难治性精神分裂症患者96例随机分为观察组（奥氮平治疗组）和对照组（氯氮平治疗组）各48例,疗程均为4周,观察两组的临床疗效.结果：观察组总有效率为89.4%;对照组总有效率为68.6%.两组对比差异显著（P〈0.01）.观察组服药过程中出现不良反应总计4例,不良反应发生率为8.3%;对照组服药过程中出现不良反应总计21例,不良反应发生率为43.7%.两组比较差异显著（P〈0.01）.结论：奥氮平治疗难治性精神分裂症效果理想,且不良反应发生少,值得临床推广使用.
Objective： Olanzapine treatment of refractory schizophrenia therapy. Methods： in our hospital from January 2008 ~ December 2c admitted 96 patients with refractory schizophrenia were randomly divided into two groups （olanzapine treatment group） and control group （cloza!c treatment group） the 48 cases, a course of 4 weeks, clinical efficacy were observed. Results： The clinical total effective rate was 89. 4% ; control group total effective rate was 68.6%. Significant difference between two groups （P〈0.01）. Observed during the placebo group, a total of four ca of adverse reactions, adverse events was 8.3%; control the process of taking a total of 21 cases of adverse reactions, adverse reaction rate was 7%. Significant difference between the two groups （P〈0. 01）. Conclusion： Olanzapine in refractory schizophrenia satisfactory results, and fewer verse events, worthy of clinical use.
