头孢呋辛钠在常用输液中的稳定性及配伍探讨

目的：建立头孢呋辛纳含量测定的方法,探讨头孢呋辛钠在常用输液中的稳定性及配伍.方法：室温条件下（25°C）,模拟临床常用浓度,采用色谱法对头孢呋辛钠与注射用水、0.9%氯化钠注射液、5%葡萄糖注射液、10%葡萄糖注射液以及5%葡萄糖氯化钠注射液配伍液体内头孢呋辛钠的含量,同时考察溶液的外观、PH值及含量的变化.结果：室温下放置6h,头孢呋辛钠与注射用水、0.9%氯化钠注射液、5%葡萄糖注射液、10%葡萄糖注射液以及5%葡萄糖氯化钠注射液配伍,其外观、pH值及含量均无明显变化.结论：头孢呋辛钠在以上5种常用输液中的配伍较为稳定,室温（25°C）下6小时无明显变化.

Objective To establish a method of determination of cefuroxime sodium, cefuroxime sodium in infusions of the stability and compatibili- ty. Methods The room temperature （25℃）, simulated clinical used concentration, using chromatography cefuroxime and water for injection, 0. 9% sodium chloride injection, 5% glucose injection, 10% and 5% glucose injection compatibility of liquid glucose and sodium chloride injection in cefuroxime sodium, also investigated the appearance of the solution, PH value and content changes. Results The room temperature 6h, cefuroxime sodium and water for injection, 0.9% sodium chloride injection, 5% glucose injection, 10% glucose injection and 5% glucose Sodium Chloride Injection, its appearance, PH value and content were not significantly changed. Conclusion cefuroxime sodium in 5 infusions over the compatibility of relatively stable at room temperature （25℃） no significant change in the next 6 hours.