肿瘤微循环血管网的数值模拟及后期处理

Numerical simulation and post-processing of tumor microvasculature

目的通过数值模拟及后处理技术获取模拟的肿瘤微血管网络结构,为研究肿瘤血液动力学和药物输送提供更趋逼真的模拟微血管网模型。方法建立具有宿主动-静脉的肿瘤血管生成模型,其中考虑了血管分叉及管径变化等因素。对模型参数作了灵敏度分析以判断模拟结果的可调控性。同时检查了血管网的连通以确保网络结构的完整性。此外,对血管网作了后期平滑处理,以减少数值网络引起的流动阻力。结果模拟结果符合肿瘤微血管网的基本形态特征,同时具有完整的循环系统、局部可调控性、网络连通性、较好的平滑度等。结论该模型可为研究肿瘤血液动力学、药物输运以及血管靶向治疗提供更趋真实可靠的血管网络数值模型。

Objective In order to provide a more realistic microvasculature model for the study on tumor hemodynamics and drug delivery,a simulated tumor microvascular network was developed by the technique of numerical simulation and post-processing. Method We constructed a tumor microvascular model with host arteriole-venule system,in which the variation in vascular branching and dimensions was taken into account. A sensitivity analysis was made for the parameters of the model to evaluate the adjustability of simulated results. The connectivity of the vascular network was tested to ensure the integrity of the network. The vascular network was smoothed afterwards to reduce flow resistance resulting from numerical networks. Results The simulated results are consistent with the characteristics of real tumor microvasculature,which show intact circulation,local adjustability,high network connectivity and smooth degree. Conclusions This study provid a numerical microvasculature model for the research on tumor hemodynamics,drug delivery and vascular-targeted therapy.