半导体激光照射对家兔皮肤伤口愈合的影响

Healing cutaneous wounds through laser irradiation

目的 探讨波长650 nm的半导体激光照射对家兔皮肤伤口愈合的影响.方法 选用21只家兔,建立伤口模型,随机分为对照组、5 mW照射组和10 mW照射组.分别在第5天、第9天和第13天,通过生物统计学方法测量并计算伤口面积变化百分数（△S）,同时行组织形态学观察.结果 5 mW照射组与对照组△S相比.差异有统计学意义（P〈0.05）;10 mW照射组与对照组△S相比,差异有统计学意义（P〈0.05）;而5 mW照射组与10 mW照射组△S相比,差异无统计学意义（P〉0.05）.2个照射组炎症消退以及胶原、新生血管和上皮的形成均优于对照组.结论 波长为650 nm、能量为1 J的半导体激光照射,选择功率5 mW或10 mW,均对家兔皮肤伤口的愈合有促进作用,且作用的差别不大.

Objective To quantify the effect of 650 nm semiconductor laser irradiation on cutaneous wound healing in rabbits. Methods Model wounds were induced in 21 adult male rabbits. They were then divided randomly into a control group, a 5 mW irradiation group and a 10 mW irradiation group. Biometry and light microscopy were used to investigate the effect of low intensity laser therapy （LILT） on cutaneous wound healing. Results Statistically significant differences were observed among the groups in terms of wound shrinkage. The differences between the irradiated and control groups were significant at the 5th, 9th and 13th day. However, any differences between the S mW and 10 mW groups were not significant. Conclusions LILT at 650 nm at either 5 mW or 10 mW and 1 J/cm^2 accelerates cutaneous wound healing in rabbits. But irradiation at 10 mW is no more effective than at 5 mW.