脑梗死患者隐匿性冠心病的相关因素

Pathogenetic predictors of coronary artery disease in patients with cerebral infarction

目的:观察和分析脑梗死患者隐匿性冠心病的相关因素。方法:104例脑梗死患者经冠状动脉造影和系统评价按是否患有隐匿性冠心病分组,观察临床特点,进行人体测量和影像学检查,分析冠心病的相关因素。结果:39例(37.5%)患者患有冠心病,多元分析显示脑梗死患者并发的冠心病与代谢综合征(OR值5.01,95%C I:1.54-16.31;P<0.01)和颅内大动脉粥样硬化(OR值4.98,95%C I:1.63-15.18;P<0.01)具有独立相关性。结论:代谢综合征和颅内大动脉粥样硬化是脑梗死患者并发隐匿性冠心病的相关因素。

AIM ： To estimate the prevalence of cardiovascular disease （CVD） in patients hospitalized for cerebral infarction and to determine the predictors of latent coronary heart disease （latent CHD ）. METHODS： One hundred and four patients with cerebral infarction without history of CVD underwent coronary angiography. Systematic evaluation was conducted on the basis of the presence of other vascular diseases, CVD risk factors and the degree of atherosclerosis. RESULTS： Thirty nine patients （37.5%） had CHD, 9（8.7% ） had carotid artery stenosis, 9（8.7% ） had peripheral artery disease of the lower limbs, and 3 （2.9%） had atheroselerotic renal artery stenosis. Multiple regression analysis showed that the presence of CHD was independently associated with metabolic syndrome （ OR 5.01,95% CI 1.54 - 16.31 ; P 〈0. 01 ） and intracranial large artery atherosclerosis （OR 4. 98, 95% CI 1.63 - 15.18 ; P 〈 0.01 ）. CONCLUSION： Patients with cerebral infarction have a high prevalence of CVD, especially latent CHD. Both metabolic syndrome and intracranial large artery atherosclerosis may be potential predictors for identifying patients with cerebral infarction who are at the highest risk for latent CAD.