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肝细胞核因子4在肝细胞分化和肝细胞癌中的作用

The Roles of HNF4 in hepatocyte differentiation and hepatocellular carcinoma
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作者 刘莹 厉建中 张俊平
机构地区 第二军医大学生化药学教研室
出处 《肝脏》 2010年第2期133-134,150,共3页 Chinese Hepatology
关键词 肝细胞核因子4 肝细胞分化 肝细胞癌 转录因子 网络调控 肝脏发育 受体家族 基因表达
分类号 R735.7 [医药卫生—肿瘤]
  • 相关文献

参考文献16

  • 1Yin C,Lin Y,Chen YX,et al.Differentiation therapy of hepatocellular in mice with recombinant adenovirus carrying hepatocyte nuclear factor-4a gene.Hepatology,2008,48(5):1528-1539.
  • 2Rausa FM,Tan Y,Costa RH.Association between HNF-6 and FoxA2 DNA binding domains stimulates FoxA2 transcriptional activity but inhibits HNF-6 DNA binding.Mol Cell Biol,2003,23(2):437-449.
  • 3Hertz R,Kalderon B,Byk T,et al.Thioesterase activity and acyl-CoA/fatty acid cross-talk of hepatocyte nuclear factor-4alpha.J Biol Chem,2005,280(26):24451-24461.
  • 4魏欣,贾战生.肝细胞核因子4在肝细胞分化和成熟中的作用[J].医学分子生物学杂志,2005,2(6):463-466. 被引量：2
  • 5Schrem H,Klempnauer J,Borlak J.Liver-enriched transcription factors in liver function and development Part I:the hepatocyte nuclear factor network and liver-specific gene expression.Pharmacol Rev,2002,54(1):129-158.
  • 6Duncan SA,Manova K,Chen W S,et al.Expression of tran-scription factor HNF-4 in the extraembryonie endoderm gut,and nephrogenic tissue of the developing mouse embryo:HNF-4 is a marker for primary endoderm in the implanting blastocyst.Proc Natl Acad Sci USA,1994,91(16):7598.
  • 7Pantelis Hatzis,Iannis Talianidis.Regulatory mechanisms controlling human hepatocyte nuclear factor 4a gene expression.Molecular And Cellular Biology,Nov,2001:7320-7330.
  • 8Chen WS,Manova K,Weinstein DC,et al.Disruption of the HNF-4 gene,expressed in visceral endoderm,leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos.Genes Dev,994,8(20):2466-2477.
  • 9Duncan SA,Nagy A,Chan W.Murine gastrulation requires HNF-4 regulated gene expression in the visceral endoderm:tetraploid rescue of Hnf-4-/-embryos.Development,1997,124(2):279-87.
  • 10Stegmann A,Hansen M,Wang Y,et al.Metabolome,trans-criptome,and bioinformatic cis-element analyses point to HNF-4 as a central regulator of gene expression during enterocyte differentiation.Physiol Genomics,2006,27(2):141-55.

二级参考文献36

  • 1Schrem H, Klempnauer J, Borlak J. Liver-enriched transcription factors in liver function and development. Part Ⅰ:the hepatocyte nuclear factor network and liver-specific gene expression. Pharmacol Rev, 2002, 54: 129-58.
  • 2Watt A J, Garrison WD, Duncan SA. HNF4: a central regulator of hepatocyte differentiation and function. Hepatology, 2003, 37 (6): 1 249-53.
  • 3Sladek FM, Zhong W, Lai E, et al. Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. Genes Dev, 1990, 4:2 35365.
  • 4Hertz R, Kalderon B, Byk T, et al. Thioesterase activity and acyl-CoA/fatty acid cross-talk of hepatocyte nuclear factor-4alpha. J Biol Chem, 2005,280 (26): 24 451-61.
  • 5Petrescu AD, Hertz R, Bar-Tana J, et al. Role of regulatory F-domain in hepatocyte nuclear factor-4alpha ligand spe1cificity. J Biol Chem, 2005, 280 (17): 16 714-27.
  • 6Chou WC, Prokova V, Shiraishi K, et al. Mechanism of a transcriptional cross talk between transforming growth factor regulated Smad3 and Smad4 proteins and orphan nuclear receptor hepatocyte nuclear factor-4. Mol Biol Cell, 2003,14:1 279-94.
  • 7Lemaigre F, Zaret KS. Liver development update: new embryo models, cell lineage control, and morphogenesis.Curr Opin Genet Dev, 2004, 14 (5): 582-90.
  • 8Odom DT, Zizlsperger N, Gordon DB, et al. Control of pancreas and liver gene expression by HNF transcription factors. Science, 2004, 303 (5 662): 1 378-81.
  • 9Duncan SA, Nagy A, Chan W. Murine gastrulation requires HNF-4 regulated gene expression in the visceral endoderm: tetraploid rescue of Hnf-4 (-/-) embryos. Development, 1997, 124 (2): 279-87.
  • 10Parviz F, Matullo C, Garrison WD, et al. Hepatocyte nuclear factor 4alpha controls the development of a hepatic epithelium and liver morphogenesis. Nat Genet, 2003, 34:292-6.

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肝脏
2010年 第2期

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