原发性肾病综合征患儿CD4^+CD25^+调节性T细胞的变化及临床意义

Change and significance of CD4^+CD25^+ regulatory cells in primary nephrotic syndrome

目的探讨原发性肾病综合征(PNS)患儿外周血淋巴细胞亚群及CD4+CD25+调节性T细胞的变化及其临床意义。方法采用流式细胞术检测23例PNS(肾病组)患儿外周血T淋巴细胞亚群,同时检测17例健康儿童作为对照组。结果 PNS患儿外周血中CD4+CD25+淋巴细胞较正常对照组明显升高(P<0.05)。结论体内异常的CD4+CD25+调节性T细胞水平参与了PNS的发病过程。PNS患儿存在细胞免疫功能紊乱,纠正或调节细胞免疫功能可应用于PNS的临床治疗。

Objective To study the change and clinical significance of T lymphocyte subsets and CD4＋CD25＋ regulatory T cells in peripheral blood in children with primary nephrotic syndrome（PNS）.Methods Peripheral blood T cells from 23 PNS patients and 17 healthy controls were collected,and the T lymphocyte subsets were detected by flow cytometry.Results The proportion of CD4＋CD25＋ regulatory T cells was higher in PNS patients than that in heathy controls（P0.05）.Conclusion The abnormal increase of CD4＋CD25＋ regulatory T cells in PNS patients may parcitipate in the development of PNS.The cellular immunity in PNS patients is in disorder.Improving the function of cellular immunity may be applied in the clinical treatment of PNS.