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嗜肺军团菌感染不同时间血清IL-12浓度的变化 被引量：1

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摘要 目的探讨嗜肺军团菌感染对机体血清白细胞介素(IL)12水平及免疫功能的影响。方法 BALB/C小鼠,实验组(又分1、2、3、4周组,n=15,各周第3天时间点观察),腹腔内注射含有嗜肺军团菌菌液0.2ml(1×106/ml),对照组(n=15),腹腔内注射无菌生理盐水0.2ml。分别在感染第1～4周内的相应时间点,采集小鼠血清,用酶联免疫吸附法(ELISA)观察血清IL-12水平的动态变化。结果感染嗜肺军团菌后第1、2、3和4周内的第3天BALB/C小鼠血清IL-12水平分别为(16.16±3.18)、(15.48±3.22)、(16.96±3.43)和(18.12±3.41)μg/ml;对照组相应时间点血清IL-12水平分别为(19.01±3.49)、(19.17±3.95)、(19.58±3.64)和(18.86±3.32)μg/ml;实验组与对照组比,第1～3周差异有统计学意义(P<0.05),而第4周差异无统计学意义(P>0.05);嗜肺军团菌感染后前2周血清IL-12水平下降,第2周达到最低,第3周有上升趋势,第4周基本恢复到正常水平。结论嗜肺军团菌感染后对机体免疫功能早期下降,后期逐渐恢复。
作者 王剑 诸葛洪祥 王春香
机构地区 镇江市第一人民医院 苏州大学病原生物学系
出处 《江苏医药》 CAS CSCD 北大核心 2010年第10期1203-1205,共3页 Jiangsu Medical Journal
关键词 嗜肺军团菌 白细胞介素12 感染
分类号 R517 [医药卫生—内科学]
  • 相关文献

参考文献9

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二级参考文献6

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共引文献2

同被引文献7

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引证文献1

江苏医药
2010年 第10期

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