胆固醇结石病的发生机制

Pathogenesis of cholesterol gallstone disease

胆石病是常见病,患病率在10%左右.近期,胆固醇结石病与代谢综合征,肠肝轴脂质代谢异常受到关注.本文论述胆固醇结石发病机制的研究领域中有关胆汁胆固醇的主要来源,肠道吸收胆固醇,胆囊运动的调节,胆固醇的载体以及代谢综合征的进展,并提出胆囊结石病基础研究的若干任务.

Cholesterol gallstone disease is a common disorder with an incidence rate of about 10%.In recent years,the research on metabolic disorders involving the gut-liver axis and the relation between gallstone disease and metabolic syndrome is attracting more attention.This article focuses on the origin of biliary cholesterol,intestinal cholesterol absorption,regulation of gallbladder motility,cholesterol transporters and metabolic syndromes and their role in the pathogenesis of gallstone disease.