摘要
随着肿瘤基因组学和蛋白组学研究领域的快速深入发展,与各种肿瘤相关的基因和蛋白已有大量报道,如何从这些海量的数据中鉴定出相关肿瘤的关键分子以用作肿瘤的防治靶点或据此了解肿瘤的发生发展机制,是肿瘤研究面临的挑战.跨种属肿瘤基因筛选策略是指通过比较不同种属同种肿瘤的基因表达谱间的相似改变,来探寻在该肿瘤发生发展中起关键作用的分子.本文对跨种属肿瘤基因筛选策略的意义及其在肝癌、肠癌和其他几种肿瘤研究中的应用进展作一概述.
The advances in genomics and proteomics have led to identification of numerous differentially expressed cancer-related genes.The current challenge in the field of cancer research is to screen the crucial molecules in carcinogenesis from the vast amounts of data.These crucial molecules can be applied as the targets for cancer prevention and therapy.In addition,identification of these crucial molecules is helpful in understanding the mechanism of carcinogenesis.Cross-species strategy refers to identification of crucial molecules in carcinogenesis by exploring the similarity between cancer-related gene expression profiles of human beings and other species.This paper reviews the recent advances in the application of this new cancer research strategy.
出处
《世界华人消化杂志》
CAS
北大核心
2010年第12期1255-1260,共6页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目
No.30560167
国家自然科学基金资助项目
No.30960428
广西壮族自治区自然科学基金资助项目
No.桂科自0728195~~
关键词
肿瘤
跨种属
关键分子
筛选
Tumor
Cross-species
Crucial molecules
Screen
