摘要
肝癌转移是一个多步骤、多因素相互作用的复杂过程.在肝癌转移复发的蛋白质组学研究方面,发现了很多新的潜在蛋白质分子标志物.由于仅用单个指标是无法进行准确预测的,采用多个指标进行联合检测将是今后肝癌转移预测的研究方向.本文综述了所涉及肝癌转移复发早诊的新型分子标志物.
The metastasis of hepatocellular carcinoma (HCC) has long been recognized as a multi-step process that involves multiple factors. Instead of diagnostic models based on single-molecule detection,the combination of multiple molecules will be the trend for early tumor diagnosis or prediction of tumor metastasis and recurrence. Many differentially expressed metastasis-asso-ciated genes and proteins have been reported in HCC. This article gives an overview of protein biomarkers for prediction of HCC metastasis and recurrence.
出处
《世界华人消化杂志》
CAS
北大核心
2010年第13期1350-1355,共6页
World Chinese Journal of Digestology
基金
国家863高科技发展计划基金资助项目
No.2006AA02A308
"艾滋病和病毒性肝炎等重大传染病防治"国家重大专项基金资助项目
No.2008ZX10002-021~~
关键词
肝癌
复发
转移
分子标志物
Hepatocellular carcinoma
Recurrence
Metastasis
Biomarker