肝癌转移、复发预测的蛋白质分子标志物

Biomarkers for prediction of metastasis and recurrence of hepatocellular carcinoma

肝癌转移是一个多步骤、多因素相互作用的复杂过程.在肝癌转移复发的蛋白质组学研究方面,发现了很多新的潜在蛋白质分子标志物.由于仅用单个指标是无法进行准确预测的,采用多个指标进行联合检测将是今后肝癌转移预测的研究方向.本文综述了所涉及肝癌转移复发早诊的新型分子标志物.

The metastasis of hepatocellular carcinoma （HCC） has long been recognized as a multi-step process that involves multiple factors. Instead of diagnostic models based on single-molecule detection,the combination of multiple molecules will be the trend for early tumor diagnosis or prediction of tumor metastasis and recurrence. Many differentially expressed metastasis-asso-ciated genes and proteins have been reported in HCC. This article gives an overview of protein biomarkers for prediction of HCC metastasis and recurrence.