摘要
甲状腺肿瘤是常见内分泌疾病,为鉴别甲状腺良、恶性病变,避免不必要的手术治疗,近年来一些学者研究外周血甲状腺肿瘤标记物.一些为甲状腺组织特异性物质,如甲状腺球蛋白（Tg）、Tg mRNA、促甲状腺激素受体（TSHR）mRNA、甲状腺过氧化物酶（TPO）mRNA、DNA甲基化物及降钙素（CT）等,其中TPO mRNA及DNA甲基化物特异性及敏感性高,而Tg敏感性易受Tg抗体影响,Tg mRNA、TSHR mRNA缺乏组织特异性.一些非甲状腺组织特异性肿瘤标记物如血管内皮生长因子、细胞角蛋白片段等在鉴别甲状腺良、恶性病变中亦有一定作用.
Thyroid tumor is a common endocrine diseases. In order to identify thyroid benign/malignant diseases, avoid unnecessary operation, some scholars study thyroid tumor markers in peripheral blood. Some of thyroid tumor markers are thyroid-specific markers,for example, thyroglobulin （Tg） , Tg mRNA, thyroid-stimulating hormone receptor（ TSHR） mRNA,thyroid peroxidase（TPO） mRNA,DNA methylation,CT and so on. TPO mRNA and DNA methylation have high sensitivity and specificity, while serum Tg is unreliable in the presence of antithyroglobulin antibodies. Tg mRNA, TSHR mRNA are lack of tissue specificity. Others are non-tissue specific markers, such as serum vascular endothelial growth factor,cytokeratin fragments , also play roles in the preoperative diagnosis of thyroid cancer.
出处
《国际内分泌代谢杂志》
2010年第3期155-158,共4页
International Journal of Endocrinology and Metabolism
