STAT3与甲状腺癌

Relationship between STAT3 and thyroid carcinoma

信号转导与转录激活因子（STAT）3是STATs家族的重要成员之一,能影响一系列基因的转录和表达,在细胞增殖、分化、衰老和凋亡中发挥重要作用.研究发现,在多种人类肿瘤细胞中均有STAT3持续性激活诱导的相应蛋白高表达,这些蛋白可以促进肿瘤发生、发展、侵袭和转移,并抑制肿瘤细胞凋亡.活化的STAT3与甲状腺癌的发生、发展及恶性生物学行为密切相关,有望成为甲状腺癌治疗的新靶标.

Signal transducer and activator of transcription 3 （STAT3） is an important member of signal transducers and activators of transcription （STATs） family. It affects series of genes＇ transcription and expression, and also plays an important role in cell proliferation, differentiation, aging and apoptosis. Researches found that corresponding proteins induced by persistent activation of STAT3 were highly expressed in variety of human tumor cells. These proteins promote the genesis, development, invasion and metastasis of tumor,also inhibit the apoptosis of tumor cell. Active STAT3 （p-STAT3） is closely related with the genesis, development and malignant behavior of thyroid carcinoma,and it is expected to be a new target for treatment of thyroid carcinoma.