利托君致不良反应文献分析

Literature Analysis of Adverse Drug Reactions Induced by Ritodrine

目的:了解利托君致不良反应(ADR)发生的特点、趋势及相关因素。方法:检索《中国期刊全文数据库》1999～2009年收载的有关利托君致ADR文献,筛选出符合卫生部ADR诊断标准的文献26篇,共337例ADR病例,并进行分类、统计、分析。结果:利托君ADR发生率为29.96%(337例/1125例);数种临床表现常合并出现,心血管系统的ADR发生率最高,有284例(占76.55%);因不能耐受而停药者占总用药人数的5.93%。结论:临床上使用利托君时应加强ADR监测,及时调整给药方法,以确保用药安全。

OBJECTIVE：To probe into the characteristics and the general pattern of adverse drug reactions（ADRs）induced by ritodrine and relevant factors. METHODS：26 literatures according with ADR diagnosis standard were retrieved from CNKI from 1999 to 2009. A total of 337 ADR cases induced by ritodrine were analyzed statistically. RESULTS：The incidence of ritodorine-inducing ADRs was 29.96%（337/1 125）. Several clinical manifestations appeared simultaneously. ADR of cardiovascular system accounted for 76.55%（n=284）. 5.93% of patients with ADR stop taking medicine because of poor drug tolerance. CONCLUSION： Great importance should be attached to ADR monitoring,adjustment of administration route to guarantee the safety of drug use.