NOD样受体在炎症反应中的调控作用

Regulation of NOD like receptors in the inflammation

天然免疫(innate immunity)是机体免疫系统直接抵御病原体入侵的最初阶段,通过机体自身的特异性模式识别受体(pattern-recognition receptors,PRRs)来识别病原体特有的保守结构病原相关分子模式(pathogen-associated molecular patterns,PAMPs)。细胞内NOD样受体(NLRs)是胞浆型PRRs中的一个重要家族,病原体侵袭细胞可上调其表达,启动机体的免疫应答和炎症反应,在机体天然免疫应答中发挥独特的功能。最近有研究证明,NLRs的突变与一些人类免疫性疾病相关,并且在细菌感染和炎症反应的控制中起重要作用。该文将讨论NLRs在炎症疾病中的调控作用。

The innate immune system is the first line of defense against microorganisms, and recognizes pathogens through pattern recognition receptors （PRRs） that detect conserved microbial components called pathogen-associated molecular patterns （PAMPs）. Nod-like receptors （NLRs） are an important family of intracellular pattern recognition receptors, which trigger immune and inflammatory responses after infection, playing a special role in innate immune system. Recently, some studies show that mutations in NLRs are associated with human immune diseases, and play an important role in infectious and inflammatory responses. In this review, we will discuss the regulation of NLRs in inflammation.