摘要
目的 探讨新辅助化疗提高食管癌手术R0切除率的可能性.方法 30例食管癌患者,其中鳞癌18例,腺癌10例,小细胞癌2例.术前新辅助化疗采用以紫杉醇联合铂类为主的方案,化疗后予以手术治疗.结果 化疗有效率（CR＋PR）56.7%（17/30）,R0切除率100%,吻合口瘘发生率3.3% （1/30）,无死亡病例.结论 新辅助化疗对提高食管癌手术R0切除率具有重要意义,对术后长期生存的影响有待进一步随访观察.
Objective To investigate the possibility of increasing R0 resection rate in esophageal carcinoma after neoadjuvant chemotherapy. Methods 30 patients underwent operation after neoadjuvant chemotherapy mainly by paclitaxel combined with cis-platinum, including 18 squamous carcinoma cases. 10 adenocarcinoma cases and 2 small cell carcinoma cases.Results In these 30 patients,the overall effective rate of neoadjuvant chemotherapy is 56.7%（17/30）（CR＋PR）,R0 resection rate is 100%,and the incidence rate of anastomotic leakage is 3.3%（1/30）,without perioperative death.Conclusion The neoadjuvant chemotherapv is significant in improving the R0 resection rate in esophageal carcinoma,and the impact of long-term survival after surgery needs further follow-up.
出处
《肿瘤研究与临床》
CAS
2010年第5期293-296,299,共5页
Cancer Research and Clinic
关键词
食管肿瘤
新辅助化疗
RO切除率
Esophageal neoplasms
Neoadjuvant chemotherapy
R0 resection rate
