二氢二醇脱氢酶和血管内皮生长因子在食管癌中的表达

Expression of DDH and VEGF in esophageal carcinoma and their relationship

目的 探讨二氢二醇脱氢酶（DDH）以及血管内皮生长因子（VEGF）在食管癌中的表达情况及两者间的相关性,并判断二者对食管癌预后的影响.方法 应用免疫组织化学方法检测61例食管癌组织及其癌旁组织中DDH和VEGF的表达情况.结果 DDH及VEGF在食管癌中的表达率[65.57%（40/61）、75.04（46/61）均高于癌旁组织的表达率[19.67%（12/61）、39.30%（24/61）]（均P=0.000）,两者的表达与患者的年龄、性别均无相关性（均P〉0.05）,而与肿瘤淋巴结转移密切相关（P=0.029,P=0.025）,二者在淋巴结转移者的表达高于无淋巴结转移者,二者无论阳性表达的患者预后差.DDH与VEGF间表达呈正相关.结论 DDH和VEGF在食管癌的发生、发展过程中有一定的相关性.

Objective To study the expression of DDH and VEGF in esophageal carcinoma and their relationship, and their prognostic significance for patients of esophageal carcinoma.Methods The expression of DDH and VEGF in 61 esophageal carcinoma tissues and border areas were detected by immunohistochemistry SABC method.Results The positive rate of DDH and VEGF in esophageal carcinoma tissues are higher than those in border areas,both of their expression were correlated with TNM stages,grades of cell differentiation and lymph node metastasis.Patients expressing DDH and VEGF seemed to have a poor prognosis.The expression of DDH was found in a positive correlation with VEGF. Conclusion DDH and VEGF were correlated with the tumorigenesis and progression of esophageal carcinoma patients.