表观遗传修饰在白血病中的作用

The function of epigenetic modification in human leukemia

在过去几年里,人们对表观遗传疾病的机制有了新的认识.人类疾病与DNA甲基化、组蛋白乙酰化和甲基化、RNA相关性沉默的表观遗传修饰有关.表观遗传修饰与细胞生长、分化、凋亡、转化及肿瘤进展相关基因的转录密切相关.长期以来人们一直认为基因突变参与肿瘤的形成,近年来越来越多的证据表明,肿瘤的形成受遗传学修饰和表观遗传修饰的影响,表观遗传修饰在肿瘤的形成中也具有非常重要的作用.现阐述了DNA甲基化、组蛋白翻译后修饰异常及小分子干扰（siRNA）对自血病形成的影响,为白血病治疗提供新的前景.

In the past few years, people have a new understanding of the mechanism of Epigenetic disease. Epigenetic modification processes involved in human disease include DNA methylation, histone acetylation and methylation, RNA-associated silencing.Epigenetic modification related with cell growth, differentiation, apoptosis, transformation and tumor progression-related gene transcription. There has been a long time that the gene mutations involved in tumor formation. In recent years.more and more evidences that genetic and epigenetic modifications leading to the formation of tumors. Epigenetic modifications has also play a very important role in the formation of tumors. This article discussed the DNA methylation.histone post-translational modification anomalies and small interference RNA impact on the formation of leukemia. It provides new prospects for the treatment of leukemia.