10种盐生植物对血管紧张肽Ⅰ-转化酶活性的影响

Study on Inhibition Activity of Angiotensin Ⅰ-Converting Enzyme (ACE) on 10 Halophytes

目的对新疆10种盐生植物提取物对血管紧张肽Ⅰ-转化酶(ACE)的抑制活性进行研究。方法通过HPLC测定马尿酸含量的变化从而推测ACE抑制活性。结果 10种盐生植物的体积分数70%乙醇提取物中,以白刺、苦豆子、芦苇的ACE抑制活性较高,IC50值分别为69.36,52.61,56.20g.L-1;水提取物中,以西伯利亚泡泡刺、琵琶柴、苦豆子、芦苇的ACE抑制活性较高,IC50值分别为55.85,63.87,40.92,10.12g.L-1。结论 10种盐生植物中部分植物提取物具有一定的抑制ACE活性。

OBJECTIVE To study the inhibition activity of ACE on 10 halophytes extracts.METHODS The inhibition activity of ACE was assayed by HPLC method.RESULTS For 70% ethanol extracts,potent inhibitory activities were showed in Nitraria tangutorum Bobr.,Sophora alopecuroides L.,Phragmites communis（L.）Trin.The IC50 values were 69.36,52.61 and 56.20 g·L^-1,respectively.For H2O extracts,potent inhibitory activities were showed in Nitraria sibirica （Pall.）,Reaumuria soongonica （PalL）Maxim.,Sophora alopecuroides L.,Phragmites communis（L.）Trin.The IC50 values of them were 55.85,63.87,40.92 and 10.12 g·L^-1,respectively.CONCLUSION Some of 10 halophytes exhibited certain potent inhibitory activity.